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Activation of lamina propria T lymphocytes in Crohn's disease
L Qiao1, G Schürmann, S C Meuer
1Applied Immunology, German Cancer Research Center, Heidelberg.
Crohn's disease is characterized by chronic inflammatory infiltrates and granuloma formation in the gut. T cell directed immunotherapy appears to be effective in relieving these symptoms. Under normal conditions, lamina propria T lymphocytes have a low proliferative response to antigen receptor stimulation in vitro due to the influence of the local intestinal environment. This study shows that lamina propria T lymphocytes exhibit an enhanced response to antigen receptor stimulation in active Crohn's disease, which may contribute in its pathogenesis.
Crohn's disease is characterized by chronic inflammatory infiltrates and granuloma formation in the gut. T cell directed immunotherapy appears to be effective in relieving these symptoms. Under normal conditions, lamina propria T lymphocytes have a low proliferative response to antigen receptor stimulation in vitro due to the influence of the local intestinal environment. This study shows that lamina propria T lymphocytes exhibit an enhanced response to antigen receptor stimulation in active Crohn's disease, which may contribute in its pathogenesis.