Experimental study of the embryogenesis of open spinal dysraphism

This article discusses the experimental studies that have been performed to make clear the embryogenesis of myeloschisis or spina bifida. Some of these theories include: Simple nonclosure; overgrowth and nonclosure; so-called reopening; overgrowth and reopening; and primary mesodermal insufficiency. The authors also discuss recent investigations and give a view into the future.