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[Renal cell carcinoma with regional lymph node metastasis]
Y Kitamura1, M Watanabe, S Komatsubara
1Department of Urology, Niigata Cancer Center Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|June 1, 1995
Summary
This study on renal cell carcinoma (kidney cancer) with lymph node metastasis found low survival rates. Early-stage metastasis (pN1) showed slightly better outcomes, but overall prognosis remained poor for advanced kidney cancer.
Area of Science:
- Urology
- Oncology
- Pathology
Context:
- Retrospective analysis of 249 renal cell carcinoma (RCC) patients treated between 1979-1993.
- Focus on 20 patients with regional lymph node metastasis (pN1-pN3).
- Investigated prognostic factors and survival rates in metastatic RCC.
Purpose:
- To evaluate the survival outcomes for renal cell carcinoma patients with regional lymph node metastasis.
- To analyze the impact of lymph node stage (pN1, pN2, pN3) and distant metastasis on patient prognosis.
- To identify potential factors influencing long-term survival in this patient cohort.
Summary:
- The 3- and 5-year survival rates for 20 RCC patients with lymph node metastasis were 45.0% and 16.4%, respectively.
- Patients with pN1 metastasis and no distant metastasis had better survival, with 2 out of 3 surviving long-term.
- Advanced stages (pN2, pN3) and distant metastasis significantly worsened prognosis, with limited long-term survival even after treatment.
Impact:
- Highlights the poor prognosis associated with lymph node metastasis in renal cell carcinoma.
- Underscores the importance of lymph node staging in predicting patient outcomes.
- Suggests limited efficacy of standard treatments for advanced metastatic RCC in the studied period.