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[Consecutive annual changes in minimum inhibitory concentration in clinically isolated Neisseria gonorrhoeae strains]
Abstract:
Between 1983 and 1991, 465 gonococcal strains isolated in the urological department of Japanese Red Cross Medical Center. The minimum inhibitory concentration (MIC) of these isolates to 22 kinds of antibiotics including penicillins (PC), cephems, tetracyclins (TC) and new quinolons (NQ) were determined and the annual difference of MIC was studied. The annual incidence of penicillinase producing neisseria gonorrhoeae (PPNG) of these 9 years were distributed in 3 to 17% and increasing tendency was not observed. As for Penicillin G, the MIC 90 of PPNG was seven fold higher than that of non-PPNG. No remarked difference was observed between MIC 90 of Cephems, TC and NQ of PPNG and non-PPNG. No annual difference was observed in MIC of PC, Cephems and SPCM. However the rising tendency of MIC was observed in NQ.
Insights
This study tracked antibiotic resistance in 465 Neisseria gonorrhoeae strains from 1983-1991. Penicillinase-producing Neisseria gonorrhoeae (PPNG) strains showed higher resistance to Penicillin G, but not other tested antibiotics.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Neisseria gonorrhoeae is a significant cause of sexually transmitted infections.
- Antimicrobial resistance in N. gonorrhoeae poses a global public health threat.
- Monitoring antibiotic susceptibility patterns is crucial for effective treatment strategies.
Purpose of the Study:
- To analyze the trends in antibiotic susceptibility of Neisseria gonorrhoeae isolates.
- To investigate the prevalence and characteristics of penicillinase-producing Neisseria gonorrhoeae (PPNG).
- To evaluate the minimum inhibitory concentrations (MICs) of various antibiotics against gonococcal strains over time.
Main Methods:
- Retrospective analysis of 465 N. gonorrhoeae isolates collected between 1983 and 1991.
- Determination of MICs for 22 antibiotics, including penicillins (PC), cephems, tetracyclins (TC), and new quinolones (NQ).
- Assessment of annual incidence of PPNG and comparison of MIC90 values between PPNG and non-PPNG strains.
Main Results:
- The incidence of PPNG ranged from 3% to 17% annually, with no clear increasing trend observed.
- PPNG strains exhibited a seven-fold higher MIC90 for Penicillin G compared to non-PPNG strains.
- MIC90 values for Cephems, Tetracyclins, and New Quinolones showed no significant difference between PPNG and non-PPNG strains.
- While MICs for Penicillin, Cephems, and SPCM remained stable, a rising tendency in MICs for New Quinolones was observed.
Conclusions:
- Penicillin G resistance in N. gonorrhoeae, particularly from PPNG strains, remained a concern during the study period.
- Emerging resistance trends, especially the rise in MICs for new quinolones, warrant continued surveillance.
- Effective management of gonorrhea requires ongoing monitoring of antimicrobial susceptibility patterns.