Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Herpes gestationis: immunologic and immunogenetic aspects]

G Messer1, H Schirren, M Meurer

  • 1Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|December 1, 1993
PubMed
Summary

Pemphigoid gestationis (PG) is an autoimmune blistering disease of pregnancy. Autoantibodies target specific antigens, and its pathogenesis involves human leukocyte antigen (HLA) associations and hormonal factors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteasome-dependent protein quality control of the peroxisomal membrane protein Pxa1p.

Biochimica et biophysica acta. Biomembranes·2020
Same author

[37-year-old male with confluent papules and arcuate erythematosquamous plaques on the upper trunk and arms : Preparation for the specialist examination: part 22].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2018
Same author

[In memory of Prof. Dr. med. Dr. h.c. mult. Otto Braun-Falco].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2018
Same author

[Systemic treatment of vitiligo : Balance and current developments].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2017
Same author

[Pigmentation disorders].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2017
Same author

[Oculocutaneous and ocular albinism].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2017

Area of Science:

  • Immunodermatology
  • Reproductive immunology

Context:

  • Pemphigoid gestationis (PG) is a rare, intensely pruritic, autoimmune blistering disease that occurs during pregnancy.
  • It is characterized by autoantibodies targeting hemidesmosome components.

Purpose:

  • To explore the immunological underpinnings of pemphigoid gestationis (PG).
  • To investigate the association between PG, human leukocyte antigens (HLA), and hormonal influences.

Summary:

  • PG involves autoantibodies against 180-kDa (BPAG2) and 230-kDa (BPAG1) antigens, crucial for dermal-epidermal adhesion.
  • A significant association exists between PG and specific HLA alleles (HLA-B8, HLA-DR3, HLA-DR4).
  • Hormonal regulation during pregnancy, potentially involving non-classical HLA-G, may contribute to PG pathogenesis.

Related Experiment Videos

Impact:

  • Understanding the immunological and genetic factors in PG pathogenesis.
  • Potential for novel diagnostic markers and therapeutic targets for autoimmune blistering diseases in pregnancy.
  • Highlights the role of immune dysregulation and hormonal factors in pregnancy-related dermatoses.