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Insulin like growth factor 1 receptor signal transduction to the nucleus
S A Rosenzweig1, B S Oemar, N M Law
1Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston 29425.
Advances in Experimental Medicine and Biology
|January 1, 1993
Abstract:
The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms triggered by IGF-1 action.