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Confocal microscopy reveals local SR calcium release in voltage-clamped cardiac cells
1Department of Physiology, University of Maryland at Baltimore 21201, USA.
Advances in Experimental Medicine and Biology
|January 1, 1995
Abstract:
Confocal microscopy during voltage-clamp depolarization of mammalian heart cells revealed distinct local [Ca2+]i-transients that resulted from Ca2+ released through sarcoplasmic reticulum (SR) release channel(s). When voltage was varied, the latency to occurrence and the relative probability of local [Ca2+]i-transients varied as predicted if SR Ca(2+)-release is linked tightly to Ca2+ flux through co-associated L-type Ca(2+)-channels.