[Nucleotide metabolism in the lymph nodes of rats with hypoxic hypoxia]

Nucleotide metabolism (pools A, G, C, U, xanthine, uric acid) in lymph nodes of two groups of white rats (the 1st model, the 2nd model) has been studied under the influence of hypoxic hypoxia (HH) with further comparative estimation of the findings. The 1st model of HH corresponded to 12 thou. m (up to the death of animals at that "height"). The nucleotide metabolism status in lymph nodes is characterized by irreversible disturbances of the nucleotide component levels and correlations. Significant tension of the nucleotide metabolism causes decompensation of the substrate-enzymatic regulation of metabolism in the lymphoid tissue. The 2nd model of HH corresponded also to 12 thou. m (up to the survival of animals at that "height"). Reversible indices of nucleotide metabolism in lymph nodes of rats are marked (deviations of the majority of indices are not so deep as in the 1st model). The reversible character of changes in the nucleotide metabolism testifies to conservation of the substrate-enzymatic self-regulation in the lymphoid tissue.