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Spindle cell lipoma is strongly CD34 positive. An immunohistochemical study
1Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Journal of Cutaneous Pathology
|December 1, 1996
Summary
Spindle cell lipoma (SCL) is a rare soft tissue tumor that can be challenging to diagnose. Immunohistochemistry, particularly CD34 staining, aids in differentiating SCL from other tumors with similar features.
Area of Science:
- Oncology
- Pathology
- Immunohistochemistry
Background:
- Spindle cell lipoma (SCL) is an uncommon soft tissue neoplasm.
- SCL can present diagnostic challenges for histopathologists due to overlapping features with other tumors.
Purpose of the Study:
- To evaluate the immunohistochemical profile of SCL.
- To identify key markers for differentiating SCL from other CD34-positive soft tissue tumors.
Main Methods:
- Retrospective analysis of four SCL cases.
- Immunohistochemical evaluation using a panel of antibodies including CD34, factor XIIIa, S-100, actin, and factor VIII.
Main Results:
- All four SCLs showed strong CD34 positivity (95-100% of cells).
- Focal positivity for factor XIIIa was observed (average 16% of cells).
- Tumor cells were negative for S-100, actin, and factor VIII.
Conclusions:
- CD34 positivity is a characteristic feature of SCL.
- Immunohistochemistry, especially CD34 and factor XIIIa staining, is crucial for distinguishing SCL from tumors like dermatofibrosarcoma protuberans, neurofibroma, schwannoma, and angiolipoma.