[The effect of lymphocytic chalone on lymphocyte functional activity in antioxidant deficiency and its correction...

Activity of lymphocyte chalone-tissue-specific inhibitor of cell proliferation and its effect on immunocompetent cells in antioxidant insufficiency (AOI) and its correction with vitamin E were studied in the work. It was stated that lymphocyte chalone quantity in AOI increased 2 times as compared with control values and was at the same level when using alpha-tocopherol acetate. The inhibiting activity of chalone was preserved in relation to the proliferative activity of lymphocytes and disappeared in relation to DNA-synthesis with immunocompetent cells. The study of fatty acids spectrum of lymphocyte membrane phospholipids has shown that lymphocyte chalone normalized the content of saturated and unsaturated fatty acids that demonstrates the antioxidant properties of lymphocyte chalone.