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Early retinal and renal abnormalities in diabetes
M A Mosier1, K H Lopez, K R Noorbaksh
1Department of Ophthalmology, University of California-Irvine 92717-4065, USA.
Journal of Diabetes and Its Complications
|July 1, 1997
Summary
Diabetic retinopathy and nephropathy early stages are not temporally related. Blood-retinal barrier and blood-glomerular barrier integrity in diabetes show independent progression, suggesting distinct temporal courses for eye and kidney complications.
Area of Science:
- Ophthalmology
- Nephrology
- Endocrinology
Background:
- Diabetic complications affect both the eye (retinopathy) and kidney (nephropathy).
- Understanding the temporal relationship between early diabetic retinopathy and nephropathy is crucial for patient management.
- Both vascular barriers are susceptible to damage in diabetes.
Purpose of the Study:
- To investigate the temporal relationship between early diabetic retinopathy and nephropathy.
- To assess the integrity of the blood-retinal barrier and blood-glomerular barrier simultaneously in diabetic individuals.
Main Methods:
- Vitreous fluorophotometry assessed the blood-retinal barrier.
- Radioimmunoassay measured 24-hour urinary albumin excretion for the blood-glomerular barrier.
- Correlation and partial correlation analyses were used.
Main Results:
- Increased posterior vitreous fluorescein leakage and urinary albumin excretion were observed in diabetic subjects.
- Leakage and albumin excretion correlated with diabetes duration but were not significantly correlated with each other.
- Hypertension affected midvitreous fluorescein levels and predicted albumin excretion independently.
Conclusions:
- Early diabetic retinopathy and nephropathy do not appear to be temporally related.
- The eye and kidney follow different temporal courses in developing functional abnormalities during early diabetes.
- Vascular barrier integrity in the eye and kidney progresses independently in early diabetes.