Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prognostic factors in colorectal carcinomas

A B Gelb1, T R Schrock

  • 1Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Connecticut 06102-5037, USA.

Surgical Oncology Clinics of North America
|July 1, 1997
PubMed
Summary

Colorectal carcinoma prognosis is influenced by established factors like stage and grade, alongside controversial biologic markers. This review examines their importance and presents pathology reporting guidelines.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Posttransplantation lymphoproliferative disorders in pediatric patients undergoing liver transplantation.

Archives of pathology & laboratory medicine·2001
Same author

The continent ileostomy: long-term durability and patient satisfaction.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·1999
Same author

Local excision of rectal carcinoma.

Archives of surgery (Chicago, Ill. : 1960)·1999
Same author

Cyclin D1 expression in renal carcinomas and oncocytomas: an immunohistochemical study.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·1998
Same author

Initiating genetic events in small renal neoplasms detected by comparative genomic hybridization.

The Journal of urology·1998
Same author

Sphincter preservation for ulcerative colitis.

The Western journal of medicine·1998

Area of Science:

  • Oncology
  • Pathology

Background:

  • Colorectal carcinoma is a major cause of cancer death.
  • Prognostic factors in colorectal cancer include clinical signs and pathological features.
  • Established factors (stage, grade) are widely accepted, while biologic/molecular markers are debated.

Purpose of the Study:

  • To review established and proposed prognostic variables for colorectal carcinoma.
  • To examine the relative importance of these variables using multivariate analyses.
  • To present reporting recommendations from the Association of Directors of Anatomic and Surgical Pathology.

Main Methods:

  • Review of multivariate analyses examining prognostic factors in colorectal carcinoma.
  • Synthesis of established and emerging prognostic variables.
  • Inclusion of guidelines for reporting colorectal carcinoma pathology.

Main Results:

  • Both traditional clinicopathologic factors and newer molecular markers impact colorectal cancer prognosis.
  • Multivariate analyses help elucidate the relative significance of various prognostic indicators.
  • Standardized reporting is crucial for consistent evaluation.

Conclusions:

  • Accurate prognostic assessment in colorectal carcinoma relies on a combination of factors.
  • Further research and consensus are needed for controversial molecular markers.
  • Adherence to standardized reporting guidelines improves patient care and research consistency.

Related Experiment Videos