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[Polyarteritis nodosa associated with hepatitis C virus]

E Hortelano Martínez1, J Calvo Catalá, M I Gonzalez-Cruz Cervellera

  • 1Sección de Reumatología y Osteoporosis, Hospital General Universitario, Valencia.

Anales De Medicina Interna (Madrid, Spain : 1984)
|May 1, 1997
PubMed

Insights

Hepatitis C virus (HCV) infection is prevalent in polyarteritis nodosa (PAN) patients, with 50% showing exclusive HCV positivity. This suggests a potential ethiopathogenic link between HCV and PAN, warranting further investigation.

Area of Science:

  • Hepatology
  • Rheumatology
  • Infectious Diseases

Background:

  • Investigating the seroprevalence of Hepatitis C Virus (HCV) in a cohort of six patients diagnosed with Polyarteritis Nodosa (PAN).
  • Assessing the potential ethiopathogenic relationship between HCV and PAN.

Observation:

  • Six patients with Polyarteritis Nodosa (PAN) underwent serodiagnosis for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV).
  • Diagnostic methods included ELISA, RIBA-II, and PCR for HCV detection.

Findings:

  • 50% of PAN patients exhibited exclusive HCV positivity across all three diagnostic methods.
  • 33.3% tested positive for HBV, 16.6% for both HBV and HCV, and one patient showed no viral positivity.

Implications:

  • The findings suggest a probable ethiopathogenic link between HCV and PAN.
  • Confirmatory testing (RIBA-II, PCR) is crucial for HCV diagnosis in PAN patients due to potential ELISA false positives from rheumatoid factors.
Abstract

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