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[Polyarteritis nodosa associated with hepatitis C virus]
E Hortelano Martínez1, J Calvo Catalá, M I Gonzalez-Cruz Cervellera
1Sección de Reumatología y Osteoporosis, Hospital General Universitario, Valencia.
Anales De Medicina Interna (Madrid, Spain : 1984)
|May 1, 1997
Summary
Hepatitis C virus (HCV) infection is prevalent in polyarteritis nodosa (PAN) patients, with 50% showing exclusive HCV positivity. This suggests a potential ethiopathogenic link between HCV and PAN, warranting further investigation.
Area of Science:
- Hepatology
- Rheumatology
- Infectious Diseases
Background:
- Investigating the seroprevalence of Hepatitis C Virus (HCV) in a cohort of six patients diagnosed with Polyarteritis Nodosa (PAN).
- Assessing the potential ethiopathogenic relationship between HCV and PAN.
Observation:
- Six patients with Polyarteritis Nodosa (PAN) underwent serodiagnosis for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV).
- Diagnostic methods included ELISA, RIBA-II, and PCR for HCV detection.
Findings:
- 50% of PAN patients exhibited exclusive HCV positivity across all three diagnostic methods.
- 33.3% tested positive for HBV, 16.6% for both HBV and HCV, and one patient showed no viral positivity.
Implications:
- The findings suggest a probable ethiopathogenic link between HCV and PAN.
- Confirmatory testing (RIBA-II, PCR) is crucial for HCV diagnosis in PAN patients due to potential ELISA false positives from rheumatoid factors.
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