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Slice profile effects in adiabatic inversion: application to multislice perfusion imaging

L R Frank1, E C Wong, R B Buxton

  • 1Department of Radiology, University of California at San Diego, USA.

Magnetic Resonance in Medicine
|November 5, 1997
PubMed
Summary
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Relaxation effects in adiabatic inversion pulses cause significant errors in arterial spin labeling perfusion imaging. Minor pulse modifications improve accuracy for quantitative, multislice perfusion measurements.

Area of Science:

  • Magnetic Resonance Imaging
  • Medical Physics
  • Physiology

Background:

  • Arterial spin labeling (ASL) is a non-invasive MRI technique used for measuring tissue perfusion.
  • Adiabatic inversion pulses are crucial for ASL but can be affected by relaxation, leading to inaccuracies.
  • Slice profile imperfections in these pulses can mimic or mask true perfusion changes.

Purpose of the Study:

  • To investigate the impact of slice profile imperfections in adiabatic inversion pulses on ASL perfusion quantitation.
  • To develop and validate modifications to inversion pulses for improved perfusion imaging accuracy.
  • To demonstrate the feasibility of quantitative, multislice perfusion imaging with corrected pulses.

Main Methods:

  • Simulated and experimental analysis of adiabatic inversion pulse performance under realistic conditions, including T1 and T2 relaxation.

Related Experiment Videos

  • Implementation of modified inversion pulses designed to minimize slice profile distortions.
  • Acquisition and analysis of ASL perfusion data in a phantom and a healthy human volunteer using both standard and modified pulses.

    • Main Results:

    • Slice profile imperfections caused signal variations comparable to actual perfusion changes, leading to substantial quantitation errors.
    • The proposed modifications to the inversion pulse significantly reduced these artifacts.
    • Quantitative, multislice perfusion images with improved accuracy were obtained in both phantom and human studies.

    Conclusions:

    • Relaxation-induced slice profile imperfections are a major source of error in ASL perfusion quantitation.
    • Minor adjustments to the inversion pulse design can substantially improve the accuracy and reliability of ASL.
    • The modified technique enables more precise, quantitative, and multislice perfusion imaging.