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Tissue remodeling with micro-structurally based material laws

P Hunter1, T Arts

  • 1Department of Engineering Science, University of Auckland, New Zealand.

Advances in Experimental Medicine and Biology
|January 1, 1997
PubMed
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Cardiomyocytes adapt to mechanical forces by changing their structure. This study models how mechanical feedback influences cardiomyocyte orientation and stiffness in the left ventricle (LV).

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Physiology
  • Computational Biology

Background:

  • Cardiomyocytes and the extracellular matrix are sensitive to mechanical stimuli.
  • Understanding these responses is crucial for cardiac health.

Purpose of the Study:

  • To investigate local mechanical feedback mechanisms.
  • To analyze their effect on myocardial microstructure and passive stiffness.

Main Methods:

  • Utilized an axisymmetric finite element model of the left ventricle (LV).
  • Employed material constitutive laws reflecting myocardial fibrous-sheet microstructure.

Main Results:

  • The model examined effects on fiber orientation.
  • Sheet orientation and passive fiber direction stiffness were analyzed.

Related Experiment Videos

  • Local mechanical feedback's role was elucidated.

    • Conclusions:

    • Mechanical feedback significantly influences cardiomyocyte and matrix organization.
    • This adaptation impacts cardiac passive stiffness.
    • Findings provide insights into cardiac mechanics.