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High prevalence of bone disorders after gastrectomy
T T Zittel1, B Zeeb, G W Maier
1University Hospital, Department of Abdominal and Transplantation Surgery, Tübingen, Germany.
American Journal of Surgery
|October 23, 1997
Summary
Gastrectomy significantly increases the risk of bone disorders, including fractures and osteopenia, due to altered calcium metabolism. This study highlights the high prevalence of postgastrectomy bone disease.
Area of Science:
- Endocrinology
- Orthopedics
- Gastroenterology
Background:
- Gastrectomy may disrupt calcium and bone metabolism, potentially leading to bone disorders.
- Limited data exists on the prevalence of bone disorders following gastrectomy.
Purpose of the Study:
- To investigate the prevalence of bone disorders in patients who have undergone gastrectomy.
- To assess alterations in calcium and bone metabolism post-gastrectomy.
Main Methods:
- Compared serum calcium and vitamin D levels in 60 gastrectomy patients (5-20 years post-op) with healthy controls.
- Radiological assessment including spinal radiographs and CT osteodensitometry in 40 patients.
Main Results:
- Gastrectomized patients showed decreased serum calcium and 25-(OH)-vitamin D, with increased parathyroid hormone and 1,25-(OH)2-vitamin D.
- High prevalence of bone disorders: 33% vertebral fractures, 45% vertebral deformities, 37% osteopenia.
- 55% of patients had vertebral fractures and/or osteopenia; risk of vertebral deformity increased sixfold.
Conclusions:
- A high prevalence of bone disorders exists in gastrectomized patients, linked to calcium metabolism disturbances.
- Postgastrectomy bone disease may stem from calcium deficits, impacting bone health and matrix calcification.