[The characteristics of an experimental infection in mice induced by salmonellae with different persistence features]

The comparative analysis of changes in the immunoreactivity of the body in (CBA x C57BL6)F1 mice in experimental infection induced by strains, differing in their plasmid profile and persistence properties, was carried out. All infected mice were found to have, on the whole, similar changes in lymphoid organs. The most severe course and outcome of the infectious process, accompanied by pronounced shifts of immunological characteristics and the activation of peroxide oxidation of lipids, were observed in mice inoculated with Salmonella typhimurium strain 178, having a polyplasmid profile and the average level of persistence factors activities.