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Updated: Aug 6, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
Published on: March 1, 2019
The cell biology of fertilization
1MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, Scotland.
Abstract:
Research into the cell biology of mammalian fertilization has been stimulated by the desire to provide a theoretical framework for the development of novel approaches to contraception and the need to understand the cellular basis of human infertility. The results of such studies have revealed a complex cascade of interactions initiated by the contact between capacitated spermatozoa on the oocyte-cumulus complex and culminating in sperm-oocyte fusion. In this review we shall examine our current understanding of the fertilization process, highlighting the strategic importance of recent findings and key areas where information is lacking.
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