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Simultaneous T2* and diffusion measurements with 3He

M Bock1

  • 1Forschungsschwerpunkt Radiologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum Heidelberg, Germany.

Magnetic Resonance in Medicine
|December 24, 1997
PubMed
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This study quantifies transversal relaxation (T2* decay) and diffusion in hyperpolarized helium-3 (3He) magnetic resonance imaging. A novel pulse sequence enables simultaneous measurement of these key parameters for lung imaging applications.

Area of Science:

  • Medical Imaging
  • Magnetic Resonance Imaging
  • Pulmonary Medicine

Background:

  • Magnetic resonance (MR) imaging of human lungs and airways is feasible using hyperpolarized gases like helium-3 (3He).
  • The impact of apparent transversal relaxation (T2* decay) and diffusion on 3He MR imaging has not been fully quantified.
  • Accurate quantification of these parameters is crucial for advancing lung imaging techniques.

Purpose of the Study:

  • To develop and validate an imaging pulse sequence for simultaneous measurement of T2* decay and diffusion in 3He MR imaging.
  • To quantify the diffusion coefficients (D) and T2* decay in both hyperpolarized and unpolarized 3He samples.
  • To assess the feasibility of these measurements on a standard clinical imager.

Main Methods:

  • Development of a novel imaging pulse sequence generating two series of multiply recalled gradient echo images.

Related Experiment Videos

  • Utilizing different echo-spacings and diffusion-sensitizing gradients within the pulse sequence.
  • Measurement of T2* and diffusion coefficients (D) by analyzing exponential signal decay differences between image series.

    • Main Results:

    • Successfully measured diffusion coefficients (D) and T2* values in hyperpolarized and Boltzmann-polarized 3He samples.
    • In pure hyperpolarized 3He, D = (1.8 ± 0.2) x 10⁻⁴ m²/s and T2* = 36 ± 13 ms were obtained.
    • In a 3He/O2 mixture, D = (0.3 ± 0.1) x 10⁻⁴ m²/s and T2* = 136 ± 66 ms were measured.

    Conclusions:

    • The developed pulse sequence effectively enables simultaneous quantification of T2* decay and diffusion in 3He MR imaging.
    • These findings provide essential quantitative data for optimizing hyperpolarized 3He lung MR imaging.
    • The method is applicable on standard clinical MRI scanners, facilitating wider research and clinical use.