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BASE imaging: a new spin labeling technique for measuring absolute perfusion changes

C Schwarzbauer1, W Heinke

  • 1Max-Planck-Institut für neuropsychologische Forschung, Leipzig, Germany.

Magnetic Resonance in Medicine
|May 15, 1998
PubMed
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A novel magnetic resonance imaging technique, BASE, accurately measures absolute perfusion changes in the brain using water proton spins. This method is effective for functional neuroimaging, providing reliable cerebral blood flow data.

Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Magnetic Resonance Imaging (MRI) is crucial for visualizing brain function.
  • Accurate measurement of absolute perfusion changes remains a challenge in neuroimaging.
  • Existing techniques may have limitations in sensitivity or applicability.

Purpose of the Study:

  • To introduce and evaluate the BASE (Basis and Selective) technique for quantifying absolute perfusion changes.
  • To assess the utility of the BASE technique in functional neuroimaging.
  • To demonstrate the application of BASE for measuring cerebral blood flow (CBF) changes during visual stimulation.

Main Methods:

  • The BASE technique utilizes magnetically labeled tissue water proton spins as a freely diffusible tracer.

Related Experiment Videos

  • It involves acquiring unprepared basis (BA) images as a reference and selective (SE) inversion prepared images sensitive to perfusion.
  • BA and SE images were alternated during visual stimulation (8 Hz checkerboard) and control periods.

    • Main Results:

    • Absolute cerebral blood flow changes (deltaCBF) were calculated from BA and SE image intensities.
    • Mean deltaCBF values in five healthy volunteers ranged from 69 +/- 18 to 99 +/- 26 ml/min/100 g.
    • The BASE technique demonstrated robustness against inversion/detection slice profile mismatches.

    Conclusions:

    • The BASE technique offers a reliable method for measuring absolute perfusion changes in functional neuroimaging.
    • Its ability to use small head coils and robustness make it a versatile tool.
    • This technique advances the quantification of cerebral blood flow dynamics.