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Genetics and aneurysm formation

W I Schievink1

  • 1Cedars-Sinai Neurosurgical Institute, Los Angeles, California, USA.

Neurosurgery Clinics of North America
|July 21, 1998
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly contribute to intracranial aneurysms. This review details heritable connective tissue disorders and familial occurrence, offering guidelines for patient evaluation and relative screening.

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Area of Science:

  • Genetics
  • Neurology
  • Vascular Biology

Background:

  • Intracranial aneurysms (IAs) are a significant cause of subarachnoid hemorrhage.
  • Genetic predisposition plays a crucial role in IA development.
  • Heritable connective tissue disorders are frequently associated with IAs.

Purpose of the Study:

  • To review the current understanding of genetic factors in intracranial aneurysm development.
  • To highlight key heritable connective tissue disorders linked to IAs.
  • To provide guidance for managing familial intracranial aneurysms.

Main Methods:

  • Literature review of genetic factors and intracranial aneurysms.
  • Detailed discussion of specific genetic disorders: autosomal dominant polycystic kidney disease, Ehlers-Danlos syndrome type IV, and alpha 1-antitrypsin deficiency.

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  • Analysis of familial occurrence rates in subarachnoid hemorrhage patients.

    • Main Results:

    • Approximately one-fifth of patients with subarachnoid hemorrhage have a familial history of aneurysms.
    • Specific genetic disorders significantly increase the risk of intracranial aneurysms.
    • Understanding genetic links aids in identifying at-risk individuals.

    Conclusions:

    • Genetic factors are integral to intracranial aneurysm pathogenesis.
    • Early identification and screening of at-risk families are essential.
    • Further research into genetic mechanisms can inform prevention and treatment strategies.