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[Serous central chorioretinopathy and endogenous hypercortisolemia]
A D Kapetanios1, G Donati, E Bouzas
1Clinique d'Ophtalmologie, Genève.
Klinische Monatsblatter Fur Augenheilkunde
|July 25, 1998
Summary
Central serous chorioretinopathy (CSC) patients show higher urinary free cortisol levels, suggesting a role for glucocorticoids in CSC pathogenesis. Further research is needed due to variability in results.
Area of Science:
- Ophthalmology
- Endocrinology
- Pathophysiology
Context:
- The pathogenic mechanisms of central serous chorioretinopathy (CSC), characterized by subretinal fluid accumulation, remain unclear.
- Previous studies indicate a higher prevalence of CSC in patients with endogenous Cushing's syndrome, hinting at a potential role for glucocorticoids.
- This study investigates endogenous cortisol secretion in CSC patients to explore the link between glucocorticoids and CSC.
Purpose:
- To assess endogenous cortisol secretion in patients diagnosed with central serous chorioretinopathy (CSC).
- To compare 24-hour urinary free cortisol (24 h-UFC) levels between CSC patients and age/sex-matched controls.
- To evaluate the potential involvement of glucocorticoids in the pathogenesis of CSC.
Summary:
- Sixteen CSC patients (35-65 years, no exogenous glucocorticoids or Cushing's syndrome) had their 24 h-UFC measured.
- CSC patients exhibited significantly higher mean 24 h-UFC levels (188.20 nmol/l ± 34.1) compared to controls (115.3 nmol/l ± 63.4).
- These preliminary findings support the hypothesis that glucocorticoids may contribute to the development of CSC.
Impact:
- Provides preliminary evidence linking elevated endogenous cortisol levels to central serous chorioretinopathy.
- Suggests that glucocorticoids could be a contributing factor in the pathogenesis of CSC.
- Highlights the need for larger studies to confirm these findings and understand the variability in cortisol levels.