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Updated: Oct 28, 2026

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing
Published on: February 4, 2017
Approaches to population kinetic analysis with application to metabolic studies
P Vicini1, P H Barrett, C Cobelli
1Department of Bioengineering, University of Washington, Seattle, USA.
Abstract:
Population kinetic analysis is the methodology traditionally used to quantify inter-subject variability in pharmacokinetic studies. In the statistics literature, it is also called analysis of repeated measurement data or analysis of longitudinal data. In this work, we will state the population kinetics problem and give some historical background to its significance. Then we will describe and apply to case studies in intermediary metabolism various two-stage and other parametric methods for nonlinear mixed effects models. We will then briefly review the software available for population kinetic analysis.
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