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Benjamin N Atkinson

8PUBLICATIONS

12CO-AUTHORS

Cheminformatics and quantitative structure-activity relationshipsMolecular targetsProteins and peptidesNatural products and bioactive compoundsBiologically active molecules

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Publications (8)

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|Oct 24, 2022

Large-scale synthesis of Notum inhibitor 1-(2,4-dichloro-3-(trifluoromethyl)-phenyl)-1<i>H</i>-1,2,3-triazole (ARUK3001185) employing a modified Sakai reaction as the key step.

Benjamin N Atkinson, Nicky J Willis, Jennifer Smith

|Jun 22, 2022

Structural Analysis and Development of Notum Fragment Screening Hits.

Yuguang Zhao, William Mahy, Nicky J Willis

|May 10, 2022

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Nicky J Willis, William Mahy, James Sipthorp

|Dec 23, 2021

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

David Steadman, Benjamin N Atkinson, Yuguang Zhao

|Aug 14, 2020

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

William Mahy, Mikesh Patel, David Steadman

|Dec 07, 2019

An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent.

Nicky J Willis, Elliott D Bayle, George Papageorgiou

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Frequent Collaborators

8 joint publications

Paul V Fish

5 joint publications

David Steadman

5 joint publications

E Yvonne Jones

5 joint publications

Nicky J Willis

4 joint publications

Hannah L Woodward

4 joint publications

Yuguang Zhao

3 joint publications

Fredrik Svensson

2 joint publications

James Sipthorp

1 joint publications

Luca Vecchia

1 joint publications

Reinis R Ruza

Frequent Collaborators

8 joint publications

Paul V Fish

5 joint publications

David Steadman

5 joint publications

E Yvonne Jones

5 joint publications

Nicky J Willis

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