Paul V Fish

17PUBLICATIONS
19CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsMolecular targetsProteins and peptidesNatural products and bioactive compoundsBiologically active molecules
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Publications (17)

|Oct 24, 2022
Large-scale synthesis of Notum inhibitor 1-(2,4-dichloro-3-(trifluoromethyl)-phenyl)-1H-1,2,3-triazole (ARUK3001185) employing a modified Sakai reaction as the key step.

Benjamin N Atkinson, Nicky J Willis, Jennifer Smith

|Jun 22, 2022
Structural Analysis and Development of Notum Fragment Screening Hits.

Yuguang Zhao, William Mahy, Nicky J Willis

|May 10, 2022
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Nicky J Willis, William Mahy, James Sipthorp

|Dec 23, 2021
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

David Steadman, Benjamin N Atkinson, Yuguang Zhao

|Apr 22, 2021
Small-molecule inhibitors of carboxylesterase Notum.

Yuguang Zhao, Sarah Jolly, Stefano Benvegnu

|Mar 30, 2021
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.

Elliott D Bayle, Fredrik Svensson, Benjamin N Atkinson

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Frequent Collaborators

8 joint publications

Benjamin N Atkinson

6 joint publications

Hannah L Woodward

6 joint publications

David Steadman

6 joint publications

Yuguang Zhao