David Steadman

8PUBLICATIONS
12CO-AUTHORS
Molecular targetsCheminformatics and quantitative structure-activity relationshipsProteins and peptidesNatural products and bioactive compoundsBiologically active molecules
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Publications (8)

|Jun 22, 2022
Structural Analysis and Development of Notum Fragment Screening Hits.

Yuguang Zhao, William Mahy, Nicky J Willis

|Dec 23, 2021
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

David Steadman, Benjamin N Atkinson, Yuguang Zhao

|Jul 22, 2021
Structural Insights into Notum Covalent Inhibition.

Yuguang Zhao, Fredrik Svensson, David Steadman

|Mar 30, 2021
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.

Elliott D Bayle, Fredrik Svensson, Benjamin N Atkinson

|Aug 14, 2020
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

William Mahy, Mikesh Patel, David Steadman

|Dec 07, 2019
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent.

Nicky J Willis, Elliott D Bayle, George Papageorgiou

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Frequent Collaborators

6 joint publications

Paul V Fish

5 joint publications

Benjamin N Atkinson

5 joint publications

E Yvonne Jones

4 joint publications

Yuguang Zhao