Nicky J Willis

6PUBLICATIONS
27CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsMolecular targetsCancer geneticsNatural products and bioactive compounds
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Publications (6)

|Oct 24, 2022
Large-scale synthesis of Notum inhibitor 1-(2,4-dichloro-3-(trifluoromethyl)-phenyl)-1H-1,2,3-triazole (ARUK3001185) employing a modified Sakai reaction as the key step.

Benjamin N Atkinson, Nicky J Willis, Jennifer Smith

|Jun 22, 2022
Structural Analysis and Development of Notum Fragment Screening Hits.

Yuguang Zhao, William Mahy, Nicky J Willis

|May 10, 2022
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Nicky J Willis, William Mahy, James Sipthorp

|Dec 23, 2021
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

David Steadman, Benjamin N Atkinson, Yuguang Zhao

|Jun 03, 2021
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Dustin J Flanagan, Nalle Pentinmikko, Kalle Luopajärvi

|Dec 07, 2019
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent.

Nicky J Willis, Elliott D Bayle, George Papageorgiou

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Frequent Collaborators

5 joint publications

Benjamin N Atkinson

5 joint publications

Paul V Fish

4 joint publications

E Yvonne Jones

3 joint publications

David Steadman