Simon Messing

8PUBLICATIONS
60CO-AUTHORS
Biomolecular modelling and designMolecular targetsCancer therapy (excl. chemotherapy and radiation therapy)Gene and molecular therapyReceptors and membrane biology
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Publications (8)

|Mar 30, 2026
Disulfide tethering reveals cryptic pockets in oncogenic KRAS.

Trent E Balius, Marcin Dyba, Vandana Kumari

|Sep 11, 2025
Structural basis for LZTR1 recognition of RAS GTPases for degradation.

Srisathiyanarayanan Dharmaiah, Daniel A Bonsor, Stephanie P Mo

|May 09, 2025
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

Anna E Maciag, Yue Yang, Alok K Sharma

|Jan 09, 2025
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.

Daniel Czyzyk, Wupeng Yan, Simon Messing

|Feb 14, 2024
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.

Matthew J Whitley, Timothy H Tran, Megan Rigby

|Jul 14, 2023
RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy.

Antonio Cuevas-Navarro, Morgan Wagner, Richard Van

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Frequent Collaborators

8 joint publications

Dhirendra K Simanshu

7 joint publications

Frank McCormick

6 joint publications

Dominic Esposito

6 joint publications

Dwight V Nissley