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Simon Messing

8PUBLICATIONS

60CO-AUTHORS

Biomolecular modelling and designMolecular targetsCancer therapy (excl. chemotherapy and radiation therapy)Gene and molecular therapyReceptors and membrane biology

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Publications (8)

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|Mar 30, 2026

Disulfide tethering reveals cryptic pockets in oncogenic KRAS.

Trent E Balius, Marcin Dyba, Vandana Kumari

|Sep 11, 2025

Structural basis for LZTR1 recognition of RAS GTPases for degradation.

Srisathiyanarayanan Dharmaiah, Daniel A Bonsor, Stephanie P Mo

|May 09, 2025

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

Anna E Maciag, Yue Yang, Alok K Sharma

|Jan 09, 2025

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.

Daniel Czyzyk, Wupeng Yan, Simon Messing

|Feb 14, 2024

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.

Matthew J Whitley, Timothy H Tran, Megan Rigby

|Jul 14, 2023

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy.

Antonio Cuevas-Navarro, Morgan Wagner, Richard Van

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Frequent Collaborators

8 joint publications

Dhirendra K Simanshu

7 joint publications

Frank McCormick

6 joint publications

Dominic Esposito

6 joint publications

Dwight V Nissley

4 joint publications

Andrew G Stephen

3 joint publications

Pau Castel

2 joint publications

Troy Taylor

2 joint publications

Timothy H Tran

2 joint publications

Oleg Chertov

2 joint publications

Matthew Drew

Frequent Collaborators

8 joint publications

Dhirendra K Simanshu

7 joint publications

Frank McCormick

6 joint publications

Dominic Esposito

6 joint publications

Dwight V Nissley

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