Dhirendra K Simanshu

33PUBLICATIONS
151CO-AUTHORS
Molecular targetsBiomolecular modelling and designChemical engineering designCancer therapy (excl. chemotherapy and radiation therapy)Structural biology (incl. macromolecular modelling)
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Publications (33)

|Oct 30, 2026
Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS.

|Apr 22, 2026
Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass.

|Mar 30, 2026
Disulfide tethering reveals cryptic pockets in oncogenic KRAS.

Trent E Balius, Marcin Dyba, Vandana Kumari

|Mar 06, 2026
Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants.

Carlos Stahlhut, Anna E Maciag, Kyle A Sullivan

|Jan 10, 2026
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors.

Daniel A Bonsor, Lorenzo I Finci, Jacob R Potter

|Sep 11, 2025
Structural basis for LZTR1 recognition of RAS GTPases for degradation.

Srisathiyanarayanan Dharmaiah, Daniel A Bonsor, Stephanie P Mo

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Frequent Collaborators

20 joint publications

Frank McCormick

16 joint publications

Dwight V Nissley

12 joint publications

Dominic Esposito

10 joint publications

Andrew G Stephen