Vignesh Narayan Hariharan

10PUBLICATIONS
42CO-AUTHORS
Gene and molecular therapyBiomolecular modelling and designBiologically active moleculesNatural language processingMedical molecular engineering of nucleic acids and proteins
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Publications (10)

|Jul 21, 2026
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality in an MECP2 duplication mouse model.

|Jan 12, 2026
Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo.

Daniel O'Reilly, Raymond C Furgal, Vella M Ross

|Jun 23, 2025
Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.

Sarah M Davis, Samuel Hildebrand, Hannah J MacMillan

|May 02, 2025
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model.

Vignesh N Hariharan, Ashley Summers, Amy E Clipperton-Allen

|Apr 08, 2025
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model.

Vignesh N Hariharan, Ashley Summers, Amy E Clipperton-Allen

|Aug 01, 2024
Enhancing siRNA efficacy in vivo with extended nucleic acid backbones.

Ken Yamada, Vignesh N Hariharan, Jillian Caiazzi

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Frequent Collaborators

8 joint publications

Anastasia Khvorova

6 joint publications

Julia F Alterman

5 joint publications

Qi Tang

5 joint publications

Ashley Summers