Andrew Zhang

9PUBLICATIONS
42CO-AUTHORS
Molecular targetsCheminformatics and quantitative structure-activity relationshipsCharacterisation of biological macromoleculesBiomolecular modelling and design
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Journal

Publications (9)

|Feb 10, 2025
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.

Jason D Shields, David Baker, Amber Y S Balazs

|Dec 10, 2024
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.

Jeffrey W Johannes, Amber Y S Balazs, Derek Barratt

|Mar 21, 2024
Integrated Proteomics Characterization of NLRP3 Inflammasome Inhibitor MCC950 in Monocytic Cell Line Confirms Direct MCC950 Engagement with Endogenous NLRP3.

Heng Zhao, Praveen Kumar, Tiago Jose Paschoal Sobreira

|Jan 16, 2024
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.

Adelphe M Mfuh, Jeffrey A Boerth, Gayathri Bommakanti

|Jan 05, 2023
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit.

Aarti Kawatkar, Roger A Clark, Lorna Hopcroft

|Sep 27, 2021
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

Jeffrey W Johannes, Amber Balazs, Derek Barratt

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Frequent Collaborators

4 joint publications

Marianne Schimpl

2 joint publications

Frederick W Goldberg

2 joint publications

Adelphe M Mfuh

2 joint publications

Jason G Kettle