Emily P Thi

6PUBLICATIONS
26CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsMedical molecular engineering of nucleic acids and proteinsBiomolecular modelling and designPharmacogenomicsBiologically active molecules
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Publications (6)

|Nov 08, 2024
Structure-Activity Relationships and Discovery of (S)-5-(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2',1':2,3]imidazo[4,5-h]quinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer.

Dimitar Gotchev, Shuai Chen, Benjamin Dugan

|Sep 22, 2024
Control of Hepatitis B Virus with Imdusiran, a Small Interfering RNA Therapeutic.

Emily P Thi, Xin Ye, Nicholas M Snead

|Sep 18, 2024
Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators.

Eugen F Mesaros, Andrew G Cole, Steven G Kultgen

|Sep 04, 2024
Rational Design, Synthesis, and Structure-Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836.

Andrew G Cole, Steven G Kultgen, Nagraj Mani

|Oct 04, 2022
Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB-506 from Phase 1 studies in healthy subjects and those with hepatitis B.

Man-Fung Yuen, Elina Berliba, Wattana Sukeepaisarnjaroen

|Apr 18, 2022
The identification of highly efficacious functionalised tetrahydrocyclopenta[c]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly.

Andrew G Cole, Steven G Kultgen, Nagraj Mani

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Frequent Collaborators

4 joint publications

Ingrid Graves

3 joint publications

Andrew G Cole

3 joint publications

Angela M Lam

2 joint publications

Robert K Suto