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rabindra.tharu.np@gmail.com
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Solvent-Free Chemical Recycling of Polyesters and Polycarbonates by Magnesium-Based Lewis Acid Catalyst
Developing a simple and efficient catalyst system for closed-loop recycling of polymers to monomers is an essentially important but challenging task for the recycle of polymer wastes and preventing the downcycle of plastic products. Herein, we employ inexpensive, commercially available Lewis acids (LAs) to achieve closed-loop recycling in bulk through the catalytic depolymerization of aliphatic…
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rabindra.tharu.np@gmail.com
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Polyoxometalates-Mediated Selectivity in Pt Single-Atoms on Ceria for Environmental Catalysis
Optimizing the reactivity and selectivity of single-atom catalysts (SACs) remains a crucial yet challenging issue in heterogeneous catalysis. This study demonstrates selective catalysis facilitated by a polyoxometalates-mediated electronic interaction (PMEI) in a Pt single-atom catalyst supported on CeO modified with Keggin-type phosphotungstate acid (HPW), labeled as Pt/CeO-HPW. The PMEI effect originates from the unique arrangement…
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rabindra.tharu.np@gmail.com
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Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes
Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, the tetrazine-triggered elimination of cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding of the underlying mechanisms, application of this reaction remains limited by…
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rabindra.tharu.np@gmail.com
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Coupling Manipulation of Interfacial Chemistry and Coordination Structure in Vanadium Oxides Enables Rapid Magnesium Ion Diffusion Kinetics
Rechargeable magnesium batteries (RMBs) are a highly promising energy storage system due to their high volumetric capacity and intrinsic safety. However, the practical development of RMBs is hindered by the sluggish Mg diffusion kinetics, including at the cathode-electrolyte interface (CEI) and within the cathode bulk. Herein, we propose an efficient strategy to manipulate the interfacial…
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rabindra.tharu.np@gmail.com
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Experimental Observation of a Terminal Borylene-Dinitrogen Adduct via Cleavage of a 1,2,3,4,5-Diboratriazoline
While azides do not react with simple alkenes except under harsh conditions, a diboron alkene analogue, the doubly cyclic alkyl(amino)carbene (CAAC)-stabilized dicyanodiborene 1, reacts spontaneously with organic azides (7-10 equiv.) at room temperature to yield two equivalents of stable CAAC-imino(cyano)boranes (2-R). NMR-spectroscopic monitoring of the reaction mixtures shows the initial formation of a 1 : 1 mixture of…
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rabindra.tharu.np@gmail.com
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Homochiral Covalent Organic Frameworks with Superhelical Nanostructures Enable Efficient Chirality-Induced Spin Selectivity
Despite significant advancements in fabricating covalent organic frameworks (COFs) with diverse morphologies, creating COFs with superhelical nanostructures remains challenging. We report here the controlled synthesis of homochiral superhelical COF nanofibers by manipulating pendent alkyl chain lengths in organic linkers. This approach yields homochiral 3D COFs 13-OR with a 10-fold interpenetrated diamondoid structure (R=H, Me, Et,…
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rabindra.tharu.np@gmail.com
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Allostery at a Protein-Protein Interface Harboring an Intermolecular Motional Network
Motional properties of proteins govern recognition, catalysis, and regulation. The dynamics of tightly interacting residues can form intramolecular dynamic networks, dependencies fine-tuned by evolution to optimize a plethora of functional aspects. The constructive interaction of residues from different proteins to assemble intermolecular dynamic networks is a similarly likely case but has escaped thorough experimental assessment…
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rabindra.tharu.np@gmail.com
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Progressive Endergonic Synthesis of Diels-Alder Adducts Driven by Chemical Energy
The overwhelming majority of artificial chemical reaction networks respond to stimuli by relaxing towards an equilibrium state. The opposite response-moving away from equilibrium-can afford the endergonic synthesis of molecules, of which only rare examples have been reported. Here, we report six examples of Diels-Alder adducts formed in an endergonic process and use this strategy to…
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rabindra.tharu.np@gmail.com
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A Double Twisted Nanographene with a Contorted Pyrene Core
The mature synthetic methodologies enable us to rationally design and produce chiral nanographenes (NGs), most of which consist of multiple helical motifs. However, inherent chirality originating from twisted geometry has just emerged to be employed in chiral NGs. Herein, we report a red-emissive chiral NG constituted of orthogonally arranged two-fold twisted π-skeletons at a contorted…
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rabindra.tharu.np@gmail.com
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Potent and Selective Oxidatively Labile Ether-Based Prodrugs through Late-Stage Boronate Incorporation
This manuscript describes a new strategy for prodrug synthesis in which a relatively inert ether group is introduced at an early stage in a synthetic sequence and functionalized in the final step to introduce a prodrug-activating group through a chemoselective process. Boryl allyloxy (BAO) ether groups are synthesized through several metal-mediated processes to form entities…
