基于液体金属纳米平台的自身癌症疫苗
Dawei Wang1,2, Zhongyang Yu3,4, Yuxia Qi3,4
1Liquid Metal and Cryogenic Biomedical Research Center, Beijing Key Lab of CryoBiomedical Engineering and Key Lab of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
ACS nano
|May 30, 2023
概括
一个基于的新型液体金属纳米平台可以在现场创建个性化的癌症疫苗. 这种方法可以摧毁瘤,增强对树突细胞的抗原呈现,并刺激系统免疫力,有效地对抗癌症.
科学领域:
- 生物材料科学 生物材料科学
- 免疫学 免疫学 免疫学
- 纳米技术纳米技术
背景情况:
- 治疗性癌症疫苗面临的挑战包括瘤异质性和免疫抑制.
- 个性化癌症疫苗需要有效的抗原捕获和免疫刺激.
- 现有的策略与抗原利用和瘤微环境作斗争.
研究的目的:
- 开发一种基于的多能液体金属 (LM) 纳米平台,用于在位进行个性化癌症疫苗 (ISCV).
- 增强抗原捕获,利用和树突细胞 (DC) 激活,以改善免疫疗法.
- 建立一个自我放大的抗瘤免疫反循环,以有效消除瘤.
主要方法:
- 使用液体金属 (LM) 纳米平台进行光热/光动力瘤破坏,以产生自身抗原.
- 使用LM纳米平台捕获抗原,将其运送到树突细胞 (DC) 和内/溶酶体逃逸.
- 将LM纳米平台与免疫检查点阻塞 (anti-PD-L1) 结合起来,以调节瘤微环境.
主要成果:
- LM纳米平台有效地摧毁了正位素瘤,产生了各种各样的自身抗原.
- 观察到增强的DC吸收,抗原利用和DC激活.
- 增强了全身抗瘤免疫力,导致瘤消除,转移抑制和复发预防.
- 组合疗法建立了一个积极的瘤杀伤性免疫反循环.
结论:
- 一个多功率的LM纳米平台显示了个性化ISCV的巨大潜力.
- 这一战略有效地克服了当前癌症疫苗开发中的关键障碍.
- 这项研究为精密免疫疗法中基于LM的免疫刺激生物材料开辟了新的途径.
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