低成本,紧的四极质量过器,通过陶树脂光聚合物化通过单位质量分辨率通过陶树脂光聚合
Colin C Eckhoff1, Nicholas K Lubinsky2, Luke J Metzler3
1Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA, 02139, USA.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 18, 2023
概括
新的3D打印四极质量过器 (QMF) 在紧的设计中提供高性能质谱. 这些增材制造的设备实现了出色的分辨率和灵敏度,使得便携式和基于太空的仪器仪表的新应用成为可能.
科学领域:
- 分析化学 分析化学
- 仪器科学 仪器科学
- 材料科学 材料科学 材料科学
背景情况:
- 质谱仪器的小型化对于便携式和现场分析至关重要.
- 传统的四极质量过器往往是庞大而昂贵的,限制了它们的广泛应用.
- 增材制造为创建复杂的,集成的微型设备提供了潜力.
研究的目的:
- 开发和描述新的,紧的,增材制造的四极质量过器 (QMF).
- 评估3D打印QMF的过性能,分辨率,灵敏度和质量范围.
- 为了证明在实际的质谱应用中使用这些设备的可行性.
主要方法:
- 使用 57 μm × 57 μm × 100 μm voxels 的玻璃陶树脂的容器光聚合,单体制造 QMF.
- -的选择性无电,用于电极形成.
- 使用1.74 MHz的FC-43进行实验性表征,以评估性能指标.
主要成果:
- 达到131Da峰值,0.50Da全宽度在最大的一半 (260分辨率).
- 显示的分辨率与商业,非微型设备相提并论,优于其他微型对应器.
- 估计灵敏度为0.13 mA Torr-1和质量范围高达250 Da.
结论:
- 附加制造的QMF为实际的质谱学提供了足够的过性能.
- 这些紧的3D打印设备代表了低成本,有能力的质谱学的重大进步.
- 该技术适用于在太空中制造复杂的仪器仪表和便携式分析设备.
相关概念视频
01:19Mass Analyzers: Common Types
615
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
615
01:13Mass Analyzers: Overview
683
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
683
00:53Filtration
826
Filtration is a physical separation process that involves passing a suspension through a porous medium to separate solids from fluids. During filtration, solids collect on the porous medium while liquids, also collectively known as the filtrate, pass through. The filtration medium is selected based on the filtration purpose, quantity, and nature of the precipitate. The general criteria for a suitable filtering medium are that it is inert, mechanically strong, nonabsorbent toward dissolved...
826