益生菌在功能性胃肠道疾病中的作用
Iva Hojsak1,2,3
1Referral Centre for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Zagreb, Croatia. iva.hojsak@kdb.hr.
Advances in experimental medicine and biology
|July 26, 2024
概括
像Limosilactobacillus reuteri和Bifidobacterium lactis这样的益生菌显示出治疗母乳养婴儿的前景. 有限的证据也支持它们用于儿童的功能性腹痛和易怒肠综合征.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物学 微生物学
- 饮食干预 饮食干预
背景情况:
- 功能性胃肠道疾病 (FGID) 在儿童中很常见,治疗选择有限.
- 饮食干预措施,特别是益生菌,越来越多地被探索为FGID管理.
- 本章回顾了当前关于儿科FGIDs益生菌疗效的证据.
研究的目的:
- 总结证据,并提供使用益生菌治疗常见儿科FGIDs的建议.
- 以最强有力的支持数据突出显示特定的益生菌菌株.
- 为儿童FGIDs提供有关益生菌补充剂的临床实践提供信息.
主要方法:
- 系统审查现有关于儿童FGIDs益生菌使用的文献.
- 分析临床试验数据和专家建议.
- 专注于特定的FGID:婴儿结肠,功能性腹痛 (FAP) 和刺激性肠综合征 (IBS).
主要成果:
- 最强有力的证据支持Limosilactobacillus (L.) reuteri DSM 17938和Bifidobacterium animalis亚种. 这两种细菌的存在. 在母乳养的婴儿中治疗婴儿结肠的Lactis BB-12.
- 有限但令人鼓舞的证据表明,乳糖菌 (Lacticaseibacillus rhamnosus GG) (LGG) 在治疗儿科IBS.
- L. reuteri DSM 17938显示了在儿童中治疗FAP的潜力.
结论:
- 特定的益生菌菌株在治疗某些儿科FGID时表现出有效性.
- 建议使用L. reuteri DSM 17938和B. lactis BB-12治疗婴儿大肠.
- 对其他FGID和益生菌菌株进行进一步的研究是有必要的.
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