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Expression of phosphatidylinositol-3 kinase in lung cancer
E S Gershtein1, V A Shatskaya, K K Laktionov
1N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow. es-gershtein@mtu-net.ru
Abstract:
The expression of phosphatidylinositol-3 kinase in tumors and homologous tissues from 29 patients with lung cancer, 5 patients with lung metastases of various tumors, and some non-tumorous pulmonary diseases was studied by Western blot analysis. The expression of phosphatidylinositol-3 kinase was increased in these tumors in comparison with histologically intact lung tissue in 5 patients with non-small-cell cancer. In 20 patients expression of phosphatidylinositol-3 kinase was the same as in homologous tissue and in 4 patients it was decreased. No relationship between phosphatidylinositol-3 kinase expression and clinical and morphological characteristics of lung cancer was revealed.