[The effect of L-arginine on the development of experimental cardiac hyperfunction and hypertrophy]

It was shown, in the investigation on laboratory rats with experimental aortic coarctation, the development of myocardial hyperfunction and hypertrophy before and under the influence of the N kappa--predecessor--L-arginine. It was found that on the 14-20 day after coarctation weight of the heart, especially of the left ventricle, and contractive activity of the papillar muscle realistically increase. Under durable infusion of L-arginine to the rats (100 mg/kg) with aortic coarctation, weight of heart and myocardial contractive activity increase more significantly than without it. N kappa--predecessor secures intracellular structures of the myocardium.