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Blockade of hyperpolarizing currents produces a dose-dependent effect on heart rate
N I Ziyatdinova1, R A Giniatullin, N V Svyatova
1Department of Human Anatomy, Physiology, and Health Care, Kazan State Pedagogical University.
Bulletin of Experimental Biology and Medicine
|June 28, 2001
Abstract:
Intravenous injection of ZD 7288, a new specific hyperpolarizing current blocker, dose-dependently reduces heart rate in adult rats. The autonomic nervous system modulates changes in heart rate caused by hyperpolarizing currents.