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A new insight into mechanisms of age-related changes in heart rate
T L Zefirov1, N V Svyatova, N I Ziyatdinova
1Department of Anatomy, Physiology, and Human Health Protection, Kazan State Pedagogical University.
Bulletin of Experimental Biology and Medicine
|October 5, 2001
Abstract:
Changes in cardiac rhythm induced by blockade of hyperpolarization currents with ZD 7288 depend on animal's age. The increase in cardiointerval duration is related to prolongation of T-P segment on ECG. It is hypothesized that the age-related changes in activity of hyperpolarization channels are determined by a modulating effect of the autonomic nervous system.