Related Experiment Video
Updated: Aug 16, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
[Does disulfiram still have a role in alcoholism treatment?]
1CTA-MP16, CHUV, 1011 Lausanne.
Abstract:
What is the place of disulfiram in the treatment of alcohol dependence since anti-craving pharmacological molecules (acamprosate, naltrexone) were launched on the market? Considering methodological limitations, available studies do not allow to conclude about disulfiram's efficacy. Clinical observations indicate however that disulfiram should keep a place in the treatment of alcohol-dependence considering favourable outcome for some patients. Disulfiram implants have however to be avoided. Side effects and possible adverse reactions should not be a barrier to its use. Disulfiram shouldn't be given during pregnancy and to patients with instable cardio-vascular disease. Its prescription justifies a close monitoring of liver tests for patients with abnormal hepatic function.
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
Conversion of Alcohols to Alkyl Halides
Drug Metabolism: Phase II Reactions
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids
Drug Therapy
Antianxiety Medications
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
