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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
[Intratympanic dexamethasone injections for intractable Meniere's disease]
Ying Huang1, Yu She, Wanrong Li
1Department of Otolaryngology-Head and Neck Surgery, the Hospital of Luzhou Medical College, Luzhou, 646000, China. hy11485@sohu.com
Objective:
To investigate the efficacy of intratympanic dexamethasone injections (IDI) and intermittent pressure (IP) for 13 patients with intractable Meniere's disease (MD).
Method:
Dexamethasone (5 g/L) was injected into the middle ear. The injection was repeated the next day and weekly for 3 weeks. Together with tympanic intermittent pressure (IP).
Result:
The 13 patients was followed up for 2-5 years. Complete relief vertigo was maintained in 9 cases,improved in 3 cases. The injection was repeated in 1 patient with recurrent vertigo and total control of vertigo was obtained. Tinnitus disappeared in 5 cases, reduced in 3 case, unchanged in 5 cases. Hearing was improved in 9 cases, unchanged in 4 cases.
Conclusion:
IDI and IP are effective for intractable MD. The benefits of IDI and IP are easy application for doctors and reasonable cost which can be accepted by patients easily.
