Comparison between GDx VCC parameter and achromatic perimetry in glaucoma patients.

Area of Science:

• Ophthalmology
• Medical Imaging
• Glaucoma Research

Background:

• Glaucoma is a leading cause of irreversible blindness.
• Accurate assessment of visual field damage is crucial for glaucoma management.
• Optical coherence tomography (OCT) and perimetry are standard diagnostic tools.

Purpose of the Study:

• To evaluate the correlation between polarimetry parameters obtained via GDx variable corneal compensator (VCC) and standard threshold perimetry indices.
• To identify which GDx VCC parameter best predicts visual field damage in glaucoma patients.

Main Methods:

• 108 glaucomatous patients underwent GDx VCC imaging and Humphrey visual field testing (24-2 SITA standard).
• Correlation coefficients were calculated between GDx VCC parameters and visual field indices (Mean Deviation, Pattern Standard Deviation).
• A linear regression model identified the most predictive GDx VCC parameter for visual field damage.

Main Results:

• Significant correlations were observed between Mean Deviation (MD) and GDx VCC parameters, notably the nerve fiber indicator (NFI) (r=-0.35).
• Significant correlations were also found between Pattern Standard Deviation (PSD) and NFI (r=0.39).
• Linear regression analysis identified NFI as the primary predictor variable for both MD and PSD.

Conclusions:

• Certain GDx VCC indices correlate significantly with visual field indices in glaucoma.
• The nerve fiber indicator (NFI) emerged as the most effective indicator of visual field damage in this cohort.
• GDx VCC, particularly NFI, shows promise as a tool for monitoring glaucoma progression.