Radiosurgery in ocular disorders: clinical applications

Area of Science:

• Ophthalmology
• Neurosurgery
• Radiation Oncology

Background:

• Ophthalmic radiosurgery presents unique challenges due to eccentric eye targets and patient positioning.
• The Leksell Gamma Knife (LGK) has demonstrated sufficient accuracy for delicate eye treatments.

Purpose of the Study:

• To evaluate the efficacy and accuracy of LGK radiosurgery for various ophthalmologic indications.
• To assess the therapeutic response of conditions including uveal melanomas, glaucoma, and age-related macular degeneration (ARMD).

Main Methods:

• Application of Leksell Gamma Knife (LGK) radiosurgery to diverse ocular pathologies.
• Patient treatment typically involves a prone position with required eye fixation.
• Utilized ultrasonography and fluorescein angiography to monitor treatment effects in ARMD patients.

Main Results:

• LGK is accurate for ophthalmic radiosurgery, with recognized outcomes for uveal melanomas.
• Gamma Knife radiosurgery on the ciliary body significantly alleviates pain and reduces intraocular pressure in advanced glaucoma.
• Initial studies indicate promising results for LGK in treating glaucoma and ARMD, showing regression or stabilization of neovascular complexes.

Conclusions:

• Leksell Gamma Knife (LGK) radiosurgery is a viable and accurate treatment modality for a spectrum of ophthalmic conditions.
• LGK offers significant benefits for advanced glaucoma and shows promise for age-related macular degeneration (ARMD).
• Further research into rare ophthalmologic indications treated with LGK is warranted.