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Related Experiment Videos

[Nephrology].

K Hadaya1, N Marangon, C Stoermann Chopard

  • 1Service de néphrologie, Département de médecine, HUG, 1211 Geneve 14.

Revue Medicale Suisse
|March 16, 2007
PubMed
Summary
This summary is machine-generated.

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Renal transplantation is now feasible despite ABO incompatibility or positive crossmatch, showing similar graft survival rates. Newer immunosuppressants also reduce calcineurin inhibitor nephrotoxicity in kidney transplant recipients.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Renal Replacement Therapy

Context:

  • ABO incompatible and positive crossmatch renal transplantation are increasingly accepted.
  • Advancements in immunosuppressive therapies have improved outcomes.
  • Peritoneal dialysis (PD) offers two main modalities: continuous ambulatory PD and automated PD.

Purpose:

  • To review current practices and outcomes in renal transplantation across ABO barriers.
  • To discuss the management of immunosuppression and its impact on nephrotoxicity.
  • To outline the principles and targets for adequate peritoneal dialysis.

Summary:

  • Renal transplantation is viable despite ABO incompatibility and positive crossmatch, with comparable graft survival to ABO-compatible transplants, though acute humoral rejection rates are higher.

Related Experiment Videos

  • The introduction of novel immunosuppressive drugs helps mitigate calcineurin inhibitor-induced nephrotoxicity.
  • Peritoneal dialysis adequacy is assessed using clinical and biological parameters, with a minimum Kt/V target of 1.7 established by recent guidelines.

    • Impact:

    • Expanded eligibility for renal transplantation, offering hope to more patients with end-stage renal disease.
    • Improved long-term renal allograft function and patient survival through optimized immunosuppression.
    • Standardized targets for peritoneal dialysis ensure effective treatment and better patient outcomes.