[Biophysical methods in assessment of the skin microcirculation system]

Area of Science:

• Biophysics
• Medical Diagnostics
• Microcirculation Research

Background:

• The microcirculatory system is crucial for tissue oxygenation and waste removal.
• Endothelial dysfunction is an early indicator of various pathological conditions.
• Chronic hepatic diseases are associated with microcirculatory impairments.

Purpose of the Study:

• To evaluate the potential of biophysics methods for assessing the microcirculatory system.
• To determine the utility of instrumental biophysics methods in detecting endothelial dysfunction.
• To explore the application of these methods in clinical investigations for early pathological condition screening.

Main Methods:

• Capillaroresistometry for microvascular resistance measurement.
• Computer capillaroscopy for detailed capillary visualization.
• Laser Doppler Flowmetry (LDF) for real-time blood flow assessment.

Main Results:

• Biophysics methods, including capillaroresistometry, computer capillaroscopy, and LDF, can effectively detect endothelial dysfunction.
• These instrumental methods provide objective estimations of microcirculatory disorders.
• LDF is particularly valuable for investigating diverse diseases and monitoring treatment efficacy.

Conclusions:

• Instrumental biophysics methods are valuable tools for the objective estimation of microcirculatory system disorders.
• These techniques facilitate the early screening of pathological conditions related to microcirculatory dysfunction.
• Laser Doppler Flowmetry offers significant potential for patient monitoring and treatment evaluation across various medical fields.