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Effect of cord blood cells on interferonogenesis and effector cells of immune system

L M Lazarenko1, O M Demchenko, L T Rachkova

  • 1D.K. Zabolotnv Institute of Microbiology and Virology National Academy of Sciences of Ukraine, Kyiv.

Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994)
|September 2, 2008
PubMed

Human cord blood cells were shown to produce interferon-alpha- and -gamma in vitro, both spontaneously and following adequate induction. Transplantation of human blood cord cells to mice led to endogenous interferonogenesis activation, serum interferon levels as well as interferon-alpha and interferon-gamma synthesis by activated peripheral blood leucocytes becoming higher. The maximal interferon accumulation in murine blood sera following transplantation did not coincide with interferonogenesis dynamics observed due to the effect of standard early and late interferon inducers - poly I:C and ridostin, respectively. Interferonogenesis activation was accompanied by increased functional activty of phagocytic system cells.

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