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Related Concept Videos

Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Fatigue Strength of Concrete01:22

Fatigue Strength of Concrete

Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
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Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Updated: Jun 27, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
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Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Fatigue: an overview.

Thomas C Rosenthal1, Barbara A Majeroni, Richard Pretorius

  • 1Department of Family Medicine, University at Buffalo, Buffalo, New York 14215, USA. trosenth@buffalo.edu

American Family Physician
|November 28, 2008
PubMed
Summary
This summary is machine-generated.

Fatigue significantly impacts daily life. Effective management involves regular exercise, targeted treatments for underlying causes, and consistent follow-up care for long-term improvement.

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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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Last Updated: Jun 27, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Area of Science:

  • General Medicine
  • Primary Care
  • Symptom Management

Background:

  • Fatigue is a prevalent symptom in primary care, affecting work, family, and social functioning.
  • Differential diagnosis includes lifestyle, physical, mental, and medication-related factors.
  • Fatigue can be categorized as secondary, physiologic, or chronic.

Purpose of the Study:

  • To outline the diagnostic approach to fatigue in primary care.
  • To present evidence-based treatment strategies for various types of fatigue.
  • To emphasize the importance of structured management and follow-up.

Main Methods:

  • Comprehensive history and physical examination to identify secondary causes and serious conditions.
  • Judicious use of laboratory studies, with repeat testing generally not indicated if initial results are normal.
  • Review of treatment options including lifestyle modifications, pharmacotherapy, and behavioral interventions.

Main Results:

  • Laboratory studies influence management in only 5% of cases.
  • Regular physical activity (stretching, aerobic exercise) is a cornerstone of fatigue management.
  • Pharmacologic options like caffeine, modafinil, and selective serotonin reuptuptake inhibitors (SSRIs) have specific applications.
  • Cognitive behavior therapy may benefit patients with chronic fatigue.

Conclusions:

  • Effective fatigue management requires a structured approach, prioritizing regular physical activity.
  • Targeted treatments, including medication and therapy, should be tailored to the specific cause and type of fatigue.
  • Consistent follow-up appointments are crucial for successful long-term management of fatigue.