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Updated: Jun 19, 2026
07:32
Dynamic Electrochemical Measurement of Chloride Ions
Published on: February 5, 2016
THE BLOOD CHLORIDES IN PROTEOSE INTOXICATION.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Proteose intoxication does not significantly alter blood chloride levels in dogs, even in fatal cases. This suggests proteose is unlikely to cause the chloride drops observed in intestinal obstruction.
Area of Science:
- Physiology
- Biochemistry
Background:
- Intestinal obstruction can lead to significant physiological changes.
- The role of specific toxins, like proteose, in these changes requires clarification.
Purpose of the Study:
- To investigate the effect of proteose intoxication on blood chloride levels in dogs.
- To determine if proteose contributes to the hypochloraemia seen in intestinal obstruction.
Main Methods:
- Dogs were injected with proteose derived from intestinal contents.
- Intravenous injections of Witte's peptone were administered.
- Autolyzing liver was introduced into the abdominal cavity.
Main Results:
- Proteose injection did not cause significant changes in blood chlorides, even with fatal intoxication.
- Witte's peptone injections resulted in minimal changes to chloride levels.
- Abdominal introduction of autolyzing liver did not affect blood chlorides despite increased urea and nonprotein nitrogen.
Conclusions:
- Proteose intoxication is unlikely to be the cause of the characteristic fall in blood chlorides observed after intestinal and pyloric obstruction.
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