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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Cell Motility through Blebbing01:16

Cell Motility through Blebbing

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Blebbing Through the Matrix
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Papillary Dermis01:11

Papillary Dermis

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Types of Membrane Protrusions

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Related Experiment Video

Updated: Jun 8, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Blue rubber bleb naevus.

R R Mittal1,

  • 1Department of Skin & VD, Medical College, Patiala, India, .

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Blue rubber bleb nevus syndrome (BRBN) is a rare vascular malformation. This case highlights a patient with only cutaneous BRBN lesions, confirmed via histopathology, showing cavernous hemangioma with smooth muscle.

Related Experiment Videos

Last Updated: Jun 8, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Area of Science:

  • Dermatology
  • Vascular Malformations
  • Histopathology

Background:

  • Blue rubber bleb nevus syndrome (BRBN) is a rare congenital disorder characterized by multiple venous malformations.
  • These malformations typically affect the skin and gastrointestinal tract, but can involve other organs.
  • Patients often present with painful, progressive, and compressible nodules.

Purpose of the Study:

  • To report a case of blue rubber bleb nevus syndrome (BRBN) presenting solely with cutaneous manifestations.
  • To emphasize the importance of histopathological confirmation in diagnosing BRBN.
  • To illustrate the clinical presentation of BRBN with unique tactile characteristics.

Main Methods:

  • Clinical examination of a 35-year-old female patient with multiple nodules.
  • Diagnostic imaging to rule out systemic abnormalities, specifically gastrointestinal hemangiomas.
  • Histopathological analysis of the cutaneous lesions to confirm the diagnosis.

Main Results:

  • The patient presented with multiple, progressive, painful, tender, soft, bluish, compressible cutaneous nodules.
  • Histopathological examination revealed cavernous hemangioma with a prominent smooth muscle outline.
  • No evidence of gastrointestinal hemangiomas or other systemic abnormalities was found.

Conclusions:

  • The diagnosis of blue rubber bleb nevus syndrome (BRBN) was confirmed, with the patient exhibiting only cutaneous lesions.
  • Histopathology is crucial for differentiating BRBN from other vascular anomalies.
  • This case underscores the variability in BRBN presentation, highlighting isolated cutaneous involvement.